In all, 9 studies have looked at how well diltiazem cream or ointment works for treating anal fissures. Only 1 of these studies looked at how well it worked compared with using no treatment. The anal fissure healed completely in 24 out of 30 adults who were using the diltiazem ointment compared with 10 out of 30 adults who were not using anything. The study had only a small number of people so this finding may not be accurate. Adults who were using the diltiazem ointment also had less pain than those who weren't receiving any treatment. Out of the 9 studies, 7 compared diltiazem cream or ointment with GTN.
For the best experience on htmlWebpackPlugin. Application of a 0. You rub a pea-sized dot of cream on the fissure twice a day. It is a good idea to either wear gloves when applying the nitroglycerin cream or wash your hands right after.
Anal Fissures: A Real Pain. Patients with anal fissures frequently seek care for pain. Anal fissures also called fissure in ano are a common affliction— second only to hemorrhoids in terms of patient complaints about the anus. However, researchers have been unable to estimate the true incidence of anal fissures.