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Anal cell cancer

The anus is an organ that lies at the end of the digestive tract below the rectum. It consists of two sections: the anal canal and the anus or anal verge. The anal canal is a cm long structure that lies between the anal sphincter one of the muscles that controls bowel movements just below the rectum and the anal verge which represents the transition point between the digestive tract and the skin on the outside of the body. Muscles within the anal canal and anus control the passage of stool from the rectum to outside the body. Cancer is when cells grow in an uncontrolled way which can lead to a tumor forming. Anal cancer is a malignant cancerous tumor of either the anal canal or anal verge.
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Anal squamous cell carcinoma: An evolution in disease and management

Anal cell cancer
Anal cell cancer
Anal cell cancer
Anal cell cancer
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Anal squamous cell carcinoma: An evolution in disease and management

The abnormal growth of cells in the anus is called anal intraepithelial neoplasia AIN or anal squamous intraepithelial lesions SILs. Tumors that develop in or on the anus are either benign noncancerous or malignant cancerous. The different types of anal cancer , listed below, are based on the type of cells in which the cancer develops:. Squamous cell carcinoma begins in the outer lining of the anal canal. It is the most common type of anal cancer. Cloacogenic carcinoma develops between the outer part of the anus and the lower part of the rectum and accounts for about 25 percent of all anal cancers.
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Anal Cancer

The inner lining of the anal canal is the mucosa. Most anal cancers start from cells in the mucosa. Glands and ducts tubes leading from the glands are found under the mucosa.
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As such, all healthcare providers need to be cognizant of the evaluation and treatment of anal squamous cell carcinoma. While chemoradiation remains the mainstay of therapy for most patients with anal cancer, surgery may still be required in recurrent, recalcitrant and palliative disease. In this manuscript, we will explore the diagnosis and management of squamous cell carcinoma of the anus. Core tip: Despite advances in the diagnosis and management, we continue to see a steady rise in the incidence of anal squamous cell cancer. The management of anal cancer has evolved from mandatory surgery to sphincter preserving therapy and is now entering an era of screening and prevention.
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Mozuru | 18.12.2017
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